Early detection of probable idiopathic Parkinson's disease: I. development of a diagnostic test battery
Identifieur interne : 002823 ( Main/Corpus ); précédent : 002822; suivant : 002824Early detection of probable idiopathic Parkinson's disease: I. development of a diagnostic test battery
Auteurs : Erwin B. Montgomery Jr. ; William C. Koller ; Theodora J. K. Lamantia ; Mary C. Newman ; Elizabeth Swanson-Hyland ; Alfred W. Kaszniak ; Kelly LyonsSource :
- Movement Disorders [ 0885-3185 ] ; 2000-05.
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Abstract
We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion‐and‐extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.
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DOI: 10.1002/1531-8257(200005)15:3<467::AID-MDS1007>3.0.CO;2-#
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Pelton Fund for Movement Disorders</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Krupa Fund</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Arizona Disease Control Research Commission</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion‐and‐extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Early detection of probable idiopathic Parkinson's disease: I. development of a diagnostic test battery</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Development of a PD Test Battery</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Early detection of probable idiopathic Parkinson's disease: I. development of a diagnostic test battery</title></titleInfo><name type="personal"><namePart type="given">Erwin B.</namePart><namePart type="family">Montgomery Jr.</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.</affiliation><description>Correspondence: Department of Neurology, Desk S90, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, U.S.A.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">William C.</namePart><namePart type="family">Koller</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>National Parkinson Foundation, University of Miami Medical Center, Miami, Florida, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Theodora J. K.</namePart><namePart type="family">LaMantia</namePart><affiliation>Department of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary C.</namePart><namePart type="family">Newman</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychology, The University of Arizona, Tucson, Arizona, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elizabeth</namePart><namePart type="family">Swanson‐Hyland</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Responsive Health Care, Overland Park, Kansas, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alfred W.</namePart><namePart type="family">Kaszniak</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychology, The University of Arizona, Tucson, Arizona, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kelly</namePart><namePart type="family">Lyons</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>National Parkinson Foundation, University of Miami Medical Center, Miami, Florida, U.S.A.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>John Wiley & Sons, Inc.</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2000-05</dateIssued><dateCaptured encoding="w3cdtf">1999-04-06</dateCaptured><dateValid encoding="w3cdtf">2000-04-05</dateValid><copyrightDate encoding="w3cdtf">2000</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="references">29</extent><extent unit="words">4008</extent></physicalDescription><abstract lang="en">We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion‐and‐extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.</abstract><note type="funding">National Institutes of Health - No. NS R01 33924; </note><note type="funding">Arizona Chapter of the American Parkinson Disease Association</note><note type="funding">Jane K. Pelton Fund for Movement Disorders</note><note type="funding">Krupa Fund</note><note type="funding">Arizona Disease Control Research Commission</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>Diagnosis</topic><topic>Movement</topic><topic>Olfaction</topic><topic>Mood</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>467</start><end>473</end><total>7</total></extent></part></relatedItem><identifier type="istex">4ED4A27F7FBBDCE4E61D75A1B4CCE9F424365BF0</identifier><identifier type="DOI">10.1002/1531-8257(200005)15:3<467::AID-MDS1007>3.0.CO;2-#</identifier><identifier type="ArticleID">MDS1007</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2000 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>John Wiley & Sons, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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